![]() ![]() However, for T1-2 tumors treated with modern chemotherapy, LRR rates are closer to 10%. Historically, loco-regional recurrence (LRR) rates after mastectomy without PMRT were about 20-30%. In the United States, post-mastectomy radiotherapy (PMRT) is generally recommended for patients with node-positive or T3-4 breast cancers ( 1, 2). All grade 3 AEs occurred in patients receiving > 60 GyE. ![]() At the last follow-up, 90% of patients were alive with no LRR or distant recurrence.Ĭonclusions: For breast cancer patients with isolated LRR after initial mastectomy without adjuvant RT, proton therapy is well-tolerated in the salvage setting with excellent loco-regional control. All patients with grade 3 AE received > 60 GyE (p=0.04, Spearman correlation coefficient=0.5). Maximum grade AE was grade 2 in 13 (69%) patients and grade 3 in 4 (21%) patients. Seventeen patients were treated with proton therapy to the chest wall and comprehensive regional lymphatics (17/19, 90%). Results: Nineteen patients were included. Follow-up and cancer outcomes were measured from the date of RT completion. ![]() Materials/Methods: Patients were identified from a multi-institutional prospective registry and included if diagnosed with invasive breast cancer, initially underwent mastectomy without adjuvant RT, experienced an LRR, and subsequently underwent salvage treatment, including proton therapy. Purpose/Objectives: To assess adverse events (AEs) and disease-specific outcomes after proton therapy for isolated local-regional recurrence (LRR) of breast cancer after mastectomy without prior radiotherapy (RT). 7New York Proton Center, New York, NY, United States.6ProCure Proton Therapy Center, Somerset, NJ, United States.5Scripps Proton Therapy Center, San Diego, CA, United States.4ProCure Proton Therapy Center, Oklahoma City, OK, United States.3Northwestern Medicine Chicago Proton Center, Warrenville, IL, United States.2Health Sciences Research, Division of Biostatistics, Mayo Clinic, Scottsdale, AZ, United States.1Department of Radiation Oncology Mayo Clinic, Phoenix, AZ, United States. ![]()
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